Peptide Database

Peptide NameLantibiotic

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length54 amino acids

Chemical FormulaC248H412N66O83S5

DescriptionStandard

        MKKNMKAIEEVSEQELKELAGGAEERAIWTVTIPISLAACPTTQCASIVSPCND
    

Molecular Weight5806.64 Da

Isoelectric Point (pI)4.72

Net Charge (pH 7.0)-3.51

Net Charge (pH 7.4) -3.79

Charge Density (pH 7.0) -0.0650

GRAVY Index-0.08

Hydrophobic Moment 0.59

Boman Index0.06

Instability Index49.06

Aliphatic Index 86.85

Aromaticity 0.0185

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5625.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2393.62

LogP -25.55

H-bond Donors 83.0

H-bond Acceptors 85.0

Rotatable Bonds 195.0

Heavy Atoms 402.0

Ring Count 5.0

Amide Bonds 57.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0183477 VERIFIED: NO

Provenance & Taxonomy

OrganismPriestia endophytica [Bacterium]

FamilyLantibiotic

Structure & Mods

Configlinear lantibiotic precursor [Linear]

Chiralitypost-translationally modified ribosomal peptide [Modified]

Other ModsLantibiotic-family precursor annotation suggests post-translational lanthionine/methyllanthionine thioether crosslinks in the mature peptide

Bio-Activity Profile

Function

Antibiotic Antimicrobial Bacteriocin Lantibiotic Anti-Gram-positive Non-hemolytic

TargetGram-positive bacteria

MethodQualitative functional evidence