Peptide Database

Peptide NameI-9

Function Ontology

Anticancer

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length14 amino acids

Chemical FormulaC88H146N24O16

DescriptionStandard

        VKRFKLFFRKLKSV
    

Molecular Weight1796.25 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)5.73

Net Charge (pH 7.4) 5.51

Charge Density (pH 7.0) 0.4093

GRAVY Index-0.07

Hydrophobic Moment 0.73

Boman Index-0.24

Instability Index1.59

Aliphatic Index 97.14

Aromaticity 0.2143

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 689.73

LogP -2.13

H-bond Donors 26.0

H-bond Acceptors 22.0

Rotatable Bonds 64.0

Heavy Atoms 128.0

Ring Count 3.0

Amide Bonds 13.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0309634 VERIFIED: YES

Provenance & Taxonomy

Organismcationic host defense peptides [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Anticancer Hemolytic

TargetRabbit red blood cells: modest hemolytic activity(as show in Fig.2)

PaperPro-apoptotic cationic host defense peptides rich in lysine or arginine to reverse drug resistance by disrupting tumor cell membrane. Amino Acids. 2017 Sep;49(9):1601-1610. doi: 10.1007/s00726-017-2453-y. PMID: 28664269. PMID28664269 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28664269/

RECORD: Rec_0358388 VERIFIED: YES

Provenance & Taxonomy

Organismcationic host defense peptides [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Anticancer

TargetK562/ADM

Activity55.6±3.3 μM

MethodIC50

PaperPro-apoptotic cationic host defense peptides rich in lysine or arginine to reverse drug resistance by disrupting tumor cell membrane. Amino Acids. 2017 Sep;49(9):1601-1610. doi: 10.1007/s00726-017-2453-y. PMID: 28664269. PMID28664269 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28664269/

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