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MYP_172495
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Basic Information
I-9
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
14 amino acids
C88H146N24O16
Standard
Sequence
VKRFKLFFRKLKSV
Physicochemical Analysis
1796.25 Da
12.00
5.73
5.51
0.4093
-0.07
0.73
-0.24
1.59
97.14
0.2143
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
689.73
-2.13
26.0
22.0
64.0
128.0
3.0
13.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0102450 VERIFIED: YES
Provenance & Taxonomy
cationic host defense peptides [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PaperPro-apoptotic cationic host defense peptides rich in lysine or arginine to reverse drug resistance by disrupting tumor cell membrane. Amino Acids. 2017 Sep;49(9):1601-1610. doi: 10.1007/s00726-017-2453-y. PMID: 28664269. PMID28664269 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28664269/
RECORD: Rec_0177965 VERIFIED: YES
Provenance & Taxonomy
cationic host defense peptides [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
MCF-7/Taxol
43.6±1.1 μM
IC50
PaperPro-apoptotic cationic host defense peptides rich in lysine or arginine to reverse drug resistance by disrupting tumor cell membrane. Amino Acids. 2017 Sep;49(9):1601-1610. doi: 10.1007/s00726-017-2453-y. PMID: 28664269. PMID28664269 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28664269/
RECORD: Rec_0201219 VERIFIED: YES
Provenance & Taxonomy
cationic host defense peptides [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
MCF-7
31.1±2.2 μM
IC50
PaperPro-apoptotic cationic host defense peptides rich in lysine or arginine to reverse drug resistance by disrupting tumor cell membrane. Amino Acids. 2017 Sep;49(9):1601-1610. doi: 10.1007/s00726-017-2453-y. PMID: 28664269. PMID28664269 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28664269/
RECORD: Rec_0225246 VERIFIED: YES
Provenance & Taxonomy
cationic host defense peptides [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
HeLa
16.5±0.4 μM
IC50
PaperPro-apoptotic cationic host defense peptides rich in lysine or arginine to reverse drug resistance by disrupting tumor cell membrane. Amino Acids. 2017 Sep;49(9):1601-1610. doi: 10.1007/s00726-017-2453-y. PMID: 28664269. PMID28664269 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28664269/
RECORD: Rec_0254940 VERIFIED: YES
Provenance & Taxonomy
cationic host defense peptides [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
K562
33.4±1.1 μM
IC50
PaperPro-apoptotic cationic host defense peptides rich in lysine or arginine to reverse drug resistance by disrupting tumor cell membrane. Amino Acids. 2017 Sep;49(9):1601-1610. doi: 10.1007/s00726-017-2453-y. PMID: 28664269. PMID28664269 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28664269/
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