Peptide Database

Peptide Namepeptide 4 (Derived from Mag2)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Standard StatusStandard

Sequence Length17 amino acids

Chemical FormulaC97H162N24O19

DescriptionStandard

        GIKKFLKSAKKFVKAFK
    

Molecular Weight1968.47 Da

Isoelectric Point (pI)10.78

Net Charge (pH 7.0)6.75

Net Charge (pH 7.4) 6.54

Charge Density (pH 7.0) 0.3972

GRAVY Index-0.24

Hydrophobic Moment 0.84

Boman Index-0.11

Instability Index-16.11

Aliphatic Index 74.71

Aromaticity 0.1765

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 731.29

LogP -2.80

H-bond Donors 26.0

H-bond Acceptors 26.0

Rotatable Bonds 73.0

Heavy Atoms 140.0

Ring Count 3.0

Amide Bonds 16.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0171709 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyMagainin

Tax ID32630

Structure & Mods

Confighydrocarbon-stapled side-chain cyclic peptide [Cyclic]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermNone

C-TermAmidation

Other ModsThe Ⓧ (position: 8 and 12) in sequence indicates (S)-4-pentenyl alanine. Ⓧ (8) and Ⓧ (12) are cross-linked by hydrocarbon stapling through an oct-4-enyl hydrocarbon staple

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetmultidrug-resistant Pseudomonas aeruginosa

Activity0.78 μM

MethodMIC

PaperMotoharu Hirano, Chihiro Saito, Hidetomo Yokoo, Chihiro Goto, Ryuji Kawano, Takashi Misawa, Yosuke Demizu. Development of Antimicrobial Stapled Peptides Based on Magainin 2 Sequence. Molecules. 2021 Jan 16;26(2):444. doi: 10.3390/molecules26020444. PMID33466998 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33466998/

RECORD: Rec_0177969 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyMagainin

Tax ID32630

Structure & Mods

Confighydrocarbon-stapled side-chain cyclic peptide [Cyclic]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermHexanoylation

C-TermAmidation

Other ModsThe Ⓧ (position: 1 and 5) in sequence indicate (S)-4-pentenyl alanine. Ⓧ (1) and Ⓧ (5) are cross-linked by hydrocarbon stapling through an oct-4-enyl hydrocarbon staple

Bio-Activity Profile

Function

Antimicrobial Antibacterial

TargetStaphylococcus aureus

Activity1.56 μM

MethodMIC

PaperMotoharu Hirano, Chihiro Saito, Hidetomo Yokoo, Chihiro Goto, Ryuji Kawano, Takashi Misawa, Yosuke Demizu. Development of Antimicrobial Stapled Peptides Based on Magainin 2 Sequence. Molecules. 2021 Jan 16;26(2):444. doi: 10.3390/molecules26020444. PMID33466998 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33466998/

RECORD: Rec_0183969 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyDefensin

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-positive Anti-Gram-negative

TargetStaphylococcus epidermidis NBRC 12298

Activity3.125 μM

MethodMIC

RECORD: Rec_0185958 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyMagainin

Tax ID32630

Structure & Mods

Confighydrocarbon-stapled side-chain cyclic peptide [Cyclic]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermNone

C-TermAmidation

Other ModsThe Ⓧ (position: 1 and 5) in sequence indicate (S)-4-pentenyl alanine. Ⓧ (1) and Ⓧ (5) are cross-linked by hydrocarbon stapling through an oct-4-enyl hydrocarbon staple

Bio-Activity Profile

Function

Antimicrobial Antibacterial

TargetEscherichia coli

Activity1.56 μM

MethodMIC

PaperMotoharu Hirano, Chihiro Saito, Hidetomo Yokoo, Chihiro Goto, Ryuji Kawano, Takashi Misawa, Yosuke Demizu. Development of Antimicrobial Stapled Peptides Based on Magainin 2 Sequence. Molecules. 2021 Jan 16;26(2):444. doi: 10.3390/molecules26020444. PMID33466998 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33466998/

RECORD: Rec_0186921 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyMagainin

Tax ID32630

Structure & Mods

Confighydrocarbon-stapled side-chain cyclic peptide [Cyclic]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermLaurylation

C-TermAmidation

Other ModsThe Ⓧ (position: 1 and 5) in sequence indicate (S)-4-pentenyl alanine. Ⓧ (1) and Ⓧ (5) are cross-linked by hydrocarbon stapling through an oct-4-enyl hydrocarbon staple

Bio-Activity Profile

Function

Antimicrobial Antibacterial

TargetPseudomonas aeruginosa

Activity12.5 μM

MethodMIC

PaperMotoharu Hirano, Chihiro Saito, Hidetomo Yokoo, Chihiro Goto, Ryuji Kawano, Takashi Misawa, Yosuke Demizu. Development of Antimicrobial Stapled Peptides Based on Magainin 2 Sequence. Molecules. 2021 Jan 16;26(2):444. doi: 10.3390/molecules26020444. PMID33466998 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33466998/

FIRST PREV 1 ... 3 4 5 6 7 ... 12 NEXT LAST

Showing 5 records on this page Ã‚Â· Page 5 of 12