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MYP_172483
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Basic Information
peptide 4 (Derived from Mag2)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
17 amino acids
C97H162N24O19
Standard
Sequence
GIKKFLKSAKKFVKAFK
Physicochemical Analysis
1968.47 Da
10.78
6.75
6.54
0.3972
-0.24
0.84
-0.11
-16.11
74.71
0.1765
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
731.29
-2.80
26.0
26.0
73.0
140.0
3.0
16.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0004375 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Magainin
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
The Ⓧ (position: 8 and 12) in sequence indicates (S)-4-pentenyl alanine. Ⓧ (8) and Ⓧ (12) are cross-linked by hydrocarbon stapling through an oct-4-enyl hydrocarbon staple
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus
6.25 μM
MIC
PaperMotoharu Hirano, Chihiro Saito, Hidetomo Yokoo, Chihiro Goto, Ryuji Kawano, Takashi Misawa, Yosuke Demizu. Development of Antimicrobial Stapled Peptides Based on Magainin 2 Sequence. Molecules. 2021 Jan 16;26(2):444. doi: 10.3390/molecules26020444. PMID33466998 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33466998/
RECORD: Rec_0012340 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Magainin
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
The Ⓧ (position: 5 and 9) in sequence indicate (S)-4-pentenyl alanine. Ⓧ (5) and Ⓧ (9) are cross-linked by hydrocarbon stapling through an oct-4-enyl hydrocarbon staple
Bio-Activity Profile
Hemolytic
human red blood cells
6.25 μM
Hemolysis
PaperMotoharu Hirano, Chihiro Saito, Hidetomo Yokoo, Chihiro Goto, Ryuji Kawano, Takashi Misawa, Yosuke Demizu. Development of Antimicrobial Stapled Peptides Based on Magainin 2 Sequence. Molecules. 2021 Jan 16;26(2):444. doi: 10.3390/molecules26020444. PMID33466998 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33466998/
RECORD: Rec_0013031 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Defensin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Hemolytic
Human erythrocyte
50 μM
Hemolysis
PMID31667994 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31667994/
RECORD: Rec_0015386 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Defensin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Anti-Gram-positive Anti-Gram-negative
Escherichia coli BBRC 3972
3.125 μM
MIC
PMID31667994 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31667994/
RECORD: Rec_0020861 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Magainin
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
The Ⓧ (position: 12 and 16) in sequence indicate (S)-4-pentenyl alanine. Ⓧ (12) and Ⓧ (16) are cross-linked by hydrocarbon stapling through an oct-4-enyl hydrocarbon staple
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli
1.56 μM
MIC
PaperMotoharu Hirano, Chihiro Saito, Hidetomo Yokoo, Chihiro Goto, Ryuji Kawano, Takashi Misawa, Yosuke Demizu. Development of Antimicrobial Stapled Peptides Based on Magainin 2 Sequence. Molecules. 2021 Jan 16;26(2):444. doi: 10.3390/molecules26020444. PMID33466998 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33466998/
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