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MYP_172459
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Basic Information
Teixobactin derivative 3
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
11 amino acids
C61H108N14O15
Standard
Sequence
FISKIISTKKI
Physicochemical Analysis
1277.59 Da
10.30
2.76
2.55
0.2506
0.62
0.24
0.16
-6.35
141.82
0.0909
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
493.07
-2.57
18.0
18.0
46.0
90.0
1.0
10.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0082156 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Methylation
N-methylated phenylalanine. Small letter denote D-amino acid. Isoleucine at 5th position is allo-isoleucine. Ester bond formation between 't' and terminal 'I'.
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
8 μg/mL
MIC
PMID30050518;28795806 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30050518/
RECORD: Rec_0135503 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Methylation
N-methylated phenylalanine. Small letter denote D-amino acid. Isoleucine at 5th position is allo-isoleucine. Ester bond formation between 't' and terminal 'I'.
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Bacillus subtilis ATCC 6051
4 μg/mL
MIC
PMID30050518;28795806 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30050518/
RECORD: Rec_0145452 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Methylation
N-methylated phenylalanine. Small letter denote D-amino acid. Isoleucine at 5th position is allo-isoleucine. Ester bond formation between 't' and terminal 'I'.
Bio-Activity Profile
Hemolytic
RBC
>64 μg/mL
Hemolysis
PMID30050518;28795806 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30050518/
RECORD: Rec_0172642 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Methylation
N-methylated phenylalanine. Small letter denote D-amino acid. Isoleucine at 5th position is allo-isoleucine. Ester bond formation between 't' and terminal 'I'.
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa ATCC 27853
64 μg/mL
MIC
PMID30050518;28795806 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30050518/
RECORD: Rec_0188408 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Methylation
N-methylated phenylalanine. Small letter denote D-amino acid. Isoleucine at 5th position is allo-isoleucine. Ester bond formation between 't' and terminal 'I'.
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
16 μg/mL
MIC
PMID30050518;28795806 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30050518/
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