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MYP_172393
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Basic Information
SAAP fraction 2 (Surfactant-associated anionic peptides; Asp-rich; sheep, ruminant, mammals, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Standard
7 amino acids
C26H35N7O20
Standard
Sequence
GDDDDDD
Physicochemical Analysis
765.59 Da
4.05
-6.23
-6.44
-0.8900
-3.06
0.21
-0.70
8.57
0.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
461.72
-7.21
14.0
14.0
25.0
53.0
0.0
6.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0114311 VERIFIED: YES
Provenance & Taxonomy
Ovis aries [Animal]
9940
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
PMID8552650 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8552650/
RECORD: Rec_0178477 VERIFIED: YES
Provenance & Taxonomy
Ovis aries [Animal]
9940
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Gram-negative bacterium: Pasteurella haemolytica (MBC50=0.04 mM in Zn-saline, MBC50=11.49 mM in Test buffer; Peptide/surfactant mixture MBC50=0.05 mM in Zn-saline, MBC50=6.44 mM in Test buffer; Peptide/serum mixture MBC50=0.05 mM in Zn-saline, MBC50=10.38 mM in Test buffer; Peptide/surfactant/serum mixture MBC50=0.06 mM in Zn-saline, MBC50=5.93 mM in Test buffer)
PMID8552650 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8552650/
RECORD: Rec_0325676 VERIFIED: NO
Provenance & Taxonomy
Ovis aries [Animal]
9940
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
RECORD: Rec_0334532 VERIFIED: YES
Provenance & Taxonomy
Ovis sp. [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Mannheimia haemolytica
PMID34203496 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34203496/
RECORD: Rec_0372587 VERIFIED: YES
Provenance & Taxonomy
Ovis aries [Animal]
9940
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
allo-residue reported
Bio-Activity Profile
Antimicrobial
in the presence of 10 uM ZnCl2. A recent study tested additional bacteria and found this peptide was inactive
>512 μg/mL
MIC
PaperIsolation of an ovine pulmonary surfactant-associated anionic peptide bactericidal for Pasteurella haemolytica