Peptide Database

Peptide NameNL6-L6A

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition

Enzyme modulation ▸ Enzyme inhibition ▸ Integrase inhibition

Standard StatusStandard

Sequence Length12 amino acids

Chemical FormulaC68H101N17O15

DescriptionStandard

        TAYFLAKLAGRW
    

Molecular Weight1396.63 Da

Isoelectric Point (pI)9.99

Net Charge (pH 7.0)1.40

Net Charge (pH 7.4) 1.20

Charge Density (pH 7.0) 0.1163

GRAVY Index0.34

Hydrophobic Moment 0.49

Boman Index0.22

Instability Index49.83

Aliphatic Index 90.00

Aromaticity 0.2500

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 6990.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 527.59

LogP -1.80

H-bond Donors 20.0

H-bond Acceptors 17.0

Rotatable Bonds 42.0

Heavy Atoms 100.0

Ring Count 4.0

Amide Bonds 11.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0322729 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antiviral

TargetHIV-1:Inhibition of 3′-processing catalyzed by integrase

Activity333 μM

MethodIC50

RECORD: Rec_0361814 VERIFIED: YES