Peptide Database

Peptide NameHMW-guanylin

Function Ontology

Hormonal / Endocrine ▸ Hormone peptide

Regulatory peptide ▸ Biological modulation

Standard StatusStandard

Sequence Length94 amino acids

Chemical FormulaC455H725N119O143S6

DescriptionStandard

        VTVQDGNFSFSLESVKKLKDLQEPQEPRVGKLRNFAPIPGEPVVPILCSNPNFPEELKPLCKEPNAQEILQRLEEIAEDPGTCEICAYAACTGC
    

Molecular Weight10342.73 Da

Isoelectric Point (pI)4.56

Net Charge (pH 7.0)-6.30

Net Charge (pH 7.4) -6.63

Charge Density (pH 7.0) -0.0670

GRAVY Index-0.34

Hydrophobic Moment 0.64

Boman Index-0.00

Instability Index63.46

Aliphatic Index 82.98

Aromaticity 0.0532

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1865.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 4166.99

LogP -40.41

H-bond Donors 138.0

H-bond Acceptors 143.0

Rotatable Bonds 336.0

Heavy Atoms 723.0

Ring Count 16.0

Amide Bonds 103.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0072411 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyHMW-guanylin

Tax ID9606

Structure & Mods

Configlinear peptide with reported disulfide constraint [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide48-61; 83-91; 86-94

Bio-Activity Profile

Function

Hormone Endocrine Receptor modulation

Half-LifeMammalian: 100 hour; Yeast: >20 hour; E. coli: >10 hour