Peptide Database

Peptide NameSLAY-screened peptide P2975

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC102H159N29O31

DescriptionStandard

        VSNDHPYRNGLALIYLNTNL
    

Molecular Weight2287.53 Da

Isoelectric Point (pI)6.71

Net Charge (pH 7.0)-0.18

Net Charge (pH 7.4) -0.44

Charge Density (pH 7.0) -0.0090

GRAVY Index-0.28

Hydrophobic Moment 0.44

Boman Index0.06

Instability Index-13.50

Aliphatic Index 117.00

Aromaticity 0.1000

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 988.59

LogP -9.87

H-bond Donors 33.0

H-bond Acceptors 32.0

Rotatable Bonds 71.0

Heavy Atoms 162.0

Ring Count 4.0

Amide Bonds 23.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0042380 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/