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MYP_172086
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Basic Information
Unnamed
Anticancer
Antimicrobial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Wound healing/Regeneration ▸ Angiogenesis modulation ▸ Anti-angiogenic
Standard
20 amino acids
C103H191N41O25
Standard
Sequence
KSVRGKGKGQKRKRKKSRYK
Physicochemical Analysis
2403.88 Da
12.00
11.75
11.53
0.5876
-2.63
0.42
-1.03
26.73
14.50
0.0500
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1175.76
-14.56
45.0
37.0
95.0
169.0
1.0
20.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0433567 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
VEGF exon 6a-derived peptide
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anti-angiogenic Anticancer
VEGF165-induced HUVEC migration
~90 % inhibition
Transwell endothelial cell migration assay (high peptide concentration)
PaperHSPG-Binding Peptide Corresponding to the Exon 6a-Encoded Domain of VEGF Inhibits Tumor Growth by Blocking Angiogenesis in Murine Model PMID20376344
RECORD: Rec_0433568 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
VEGF exon 6a-derived peptide
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anti-angiogenic Anticancer
Mouse Lewis lung carcinoma xenograft tumor size
~30 % reduction
In vivo tumor-growth assay (6a-P treatment)
PaperHSPG-Binding Peptide Corresponding to the Exon 6a-Encoded Domain of VEGF Inhibits Tumor Growth by Blocking Angiogenesis in Murine Model PMID20376344
RECORD: Rec_0433569 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
VEGF exon 6a-derived peptide
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anti-angiogenic Anticancer
Human liposarcoma xenograft tumor size
~36 % reduction
In vivo xenograft tumor-growth assay (high-dose 6a-P)
PaperHSPG-Binding Peptide Corresponding to the Exon 6a-Encoded Domain of VEGF Inhibits Tumor Growth by Blocking Angiogenesis in Murine Model PMID20376344
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