Peptide Database

Peptide NameSLAY-screened peptide P645

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC109H160N34O29S2

DescriptionStandard

        PNRVHDPCSMYTVYRKFHHS
    

Molecular Weight2474.78 Da

Isoelectric Point (pI)9.26

Net Charge (pH 7.0)2.21

Net Charge (pH 7.4) 1.98

Charge Density (pH 7.0) 0.1104

GRAVY Index-1.10

Hydrophobic Moment 0.52

Boman Index-0.24

Instability Index1.10

Aliphatic Index 29.00

Aromaticity 0.1500

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1010.84

LogP -10.06

H-bond Donors 38.0

H-bond Acceptors 36.0

Rotatable Bonds 75.0

Heavy Atoms 174.0

Ring Count 8.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0418254 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/