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MYP_171863
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Basic Information
hEP-3
Antimicrobial
Antiviral
Antiviral ▸ Anti-Hepatitis virus ▸ Anti-HCV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Standard
30 amino acids
C158H245N43O49S2
Standard
Sequence
CEEQAQQIRLQAEAFQARLKSWFEPLVEDM
Physicochemical Analysis
3595.02 Da
4.42
-3.24
-3.46
-0.1079
-0.58
0.53
-0.11
54.25
75.00
0.1000
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1523.52
-12.45
51.0
48.0
122.0
252.0
5.0
34.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0014321 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
5
PaperPubMed PMID: 22334503 PMID22334503 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22334503/
RECORD: Rec_0045005 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Hepatitis C virus (HCV) JFH-1
PMID22334503 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22334503/
RECORD: Rec_0091044 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HCV Entry inhibition
Hepatitis C virus (HCVpp) | Huh7.5.1 cells
10 μM
IC50
Mammalian: 1.2 h; Yeast: >20 h; E. coli: >10 h
PaperHuman apolipoprotein E peptides inhibit hepatitis C virus entry by blocking virus binding. | Liu S, McCormick KD, Zhao W, Zhao T, Fan D, Wang T. | Hepatology. 2012 Aug;56(2):484-91. | DOI:10.1002/hep.25665 | PMID:22334503 PMID22334503 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22334503/
RECORD: Rec_0092773 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Apolipoprotein-derived
9606;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Entry inhibitor
Hepatitis C virus (Virus entry); Huh7.5.1
10 μM
RT-PCR
PaperHuman apolipoprotein E peptides inhibit hepatitis C virus entry by blocking virus binding. | Liu S, McCormick KD, Zhao W, Zhao T, Fan D, Wang T. | Hepatology. 2012 | PMID:22334503 PMID22334503 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22334503/
RECORD: Rec_0149309 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 60.0%, E 6.7%, T 20.0%, C 13.3% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/
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