Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length440 amino acids

Chemical FormulaC2168H3465N547O623S20

DescriptionStandard

        MSPCCCLALLALLPFALATNPGVKVKLTEKGIEYGKQIGMASLQQKLKTMKVPDLSGTERVAPIGKVKYSLTGITIVNLGLPYSALALVPDTGIRLSITNAFISLHGNWKIRYLSFIKDSGSFDLEVNGLTVTDSITIKSDETGRPTVSSVNCVANVGSASIKFHGGARNIYIFCHLEVLAKVDKYAEVEYSMVTSPTISNTSIDFSLKGEFYNIGKHQEPPFSPTPFSLPPQVNNMLYIGMSAFTTNSAGFVYNNAGALSLYITDDMIPPSSPIRLNTRTFGAFIPEIAKRFPSMMMKLLVKTVKEPTIFFEPNNVTVQASGSVTAYAIQPNTTLSPLFVLNMGSVSARLYVTGVKLAGAVTLNKIEMTLETSYVGQFQVRSLDNIFLMVLKVAVIPKVNARLEKGFPLPSIGKMNLVNTQLQVLKDYMLIGTDVQFTG
    

Molecular Weight47802.29 Da

Isoelectric Point (pI)9.20

Net Charge (pH 7.0)9.82

Net Charge (pH 7.4) 9.22

Charge Density (pH 7.0) 0.0223

GRAVY Index0.21

Hydrophobic Moment 0.64

Boman Index0.17

Instability Index30.36

Aliphatic Index 99.66

Aromaticity 0.0864

Extinction Coeff. Reduced 27850.00

Extinction Coeff. Oxidized 28100.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0150851 VERIFIED: NO

Provenance & Taxonomy

OrganismOncorhynchus tshawytscha [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria

MethodQualitative functional evidence