Peptide Database

Peptide NameDefensin-1

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Antimicrobial ▸ Antifungal ▸ Anti-Candida

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length83 amino acids

Chemical FormulaC392H634N110O109S12

DescriptionStandard

        MAGKGVGSRLSTLFLLVLLVITIGMMQVQVAEGRMCKTPSGKFKGYCVNNTNCKNVCRTEGFPTGSCDFHVAGRKCYCYKPCP
    

Molecular Weight9016.68 Da

Isoelectric Point (pI)9.30

Net Charge (pH 7.0)7.50

Net Charge (pH 7.4) 7.10

Charge Density (pH 7.0) 0.0904

GRAVY Index0.10

Hydrophobic Moment 0.48

Boman Index0.07

Instability Index10.36

Aliphatic Index 69.16

Aromaticity 0.0843

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4970.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3506.21

LogP -37.15

H-bond Donors 130.0

H-bond Acceptors 130.0

Rotatable Bonds 297.0

Heavy Atoms 623.0

Ring Count 12.0

Amide Bonds 88.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0026751 VERIFIED: YES

Provenance & Taxonomy

OrganismPinus sylvestris [other]

FamilyDefensin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidedisulfide bond; sites not specified

Bio-Activity Profile

Function

Antimicrobial Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetEscherichia coli

RECORD: Rec_0145240 VERIFIED: YES

Provenance & Taxonomy

OrganismPinus sylvestris [other]

FamilyDefensin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidedisulfide bond; sites not specified

Bio-Activity Profile

Function

Antimicrobial Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetFusarium oxysporum

RECORD: Rec_0196702 VERIFIED: YES

Provenance & Taxonomy

OrganismPinus sylvestris [other]

FamilyDefensin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidedisulfide bond; sites not specified

Bio-Activity Profile

Function

Antimicrobial Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetCandida albicans

RECORD: Rec_0206971 VERIFIED: YES

Provenance & Taxonomy

OrganismPinus sylvestris [other]

FamilyDefensin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidedisulfide bond; sites not specified

Bio-Activity Profile

Function

Antimicrobial Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetFusarium solani

RECORD: Rec_0418777 VERIFIED: YES

Provenance & Taxonomy

OrganismPinus sylvestris [other]

FamilyDefensin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidedisulfide bond; sites not specified

Bio-Activity Profile

Function

Antimicrobial Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetH. annosum