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MYP_171785
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Basic Information
Glucagon like peptide 1 [7-36]
Binding / Molecular interaction ▸ Binding activity
Hormonal / Endocrine ▸ Hormone peptide
Metabolic
Metabolic ▸ Appetite and feeding regulation ▸ Feeding regulator
Metabolic ▸ Glucose metabolism ▸ Antidiabetic
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell-cell communication
Standard
30 amino acids
C149H225N39O46
Standard
Sequence
HAEGTFTSDVSSYLEGQAAKEFIAWLVKGR
Physicochemical Analysis
3298.61 Da
5.53
-1.15
-1.41
-0.0382
-0.23
0.48
0.08
17.69
71.67
0.1333
6990.00
6990.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1379.30
-13.40
49.0
46.0
108.0
234.0
6.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0330036 VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]
Glucagon
9823
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Hormone Metabolic
PMID2753890 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2753890/
RECORD: Rec_0343479 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
GLP-1
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Radiolabelling of GLP-1by [123I]
Bio-Activity Profile
Antidiabetic
Scintigraphy
NEDH Rats (rat tumour model), in vivo; 420 s
PMID11976797 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11976797/
RECORD: Rec_0344260 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
GLP-1
9606
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
Amidation
X-1 = Cys- conjugated-7-hydroxyCoumarin maleimide
Bio-Activity Profile
Receptor-binding
EC50
Rat Plasma, in vitro; 46440 s
PMID25039358 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25039358/
RECORD: Rec_0348692 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
GLP-1
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
None
Bio-Activity Profile
Insulinotropic
5600 μM
LC/MS equipped with a microbore C-18 HPLC
Human plasma, in vitro; >43200 s
PMID15012592 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15012592/
RECORD: Rec_0349388 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
GLP-1
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Regulates blood glucose levels
RP-HPLC
Rat intestinal homogenate, in vitro; 47.4 s
PMID17904340 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17904340/
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