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MYP_171785
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Basic Information
Glucagon like peptide 1 [7-36]
Binding / Molecular interaction ▸ Binding activity
Hormonal / Endocrine ▸ Hormone peptide
Metabolic
Metabolic ▸ Appetite and feeding regulation ▸ Feeding regulator
Metabolic ▸ Glucose metabolism ▸ Antidiabetic
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell-cell communication
Standard
30 amino acids
C149H225N39O46
Standard
Sequence
HAEGTFTSDVSSYLEGQAAKEFIAWLVKGR
Physicochemical Analysis
3298.61 Da
5.53
-1.15
-1.41
-0.0382
-0.23
0.48
0.08
17.69
71.67
0.1333
6990.00
6990.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1379.30
-13.40
49.0
46.0
108.0
234.0
6.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0312696 VERIFIED: YES
Provenance & Taxonomy
Canis lupus familiaris [Animal]
Glucagon-like peptide 1(7-36)
9615
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Amidation
8:Phosphoserine; 11:Phosphoserine
Bio-Activity Profile
Hormone Endocrine Neuropeptide Neuromodulator Metabolic regulation Physiological regulation Growth regulation Development regulation Receptor modulation
peripheral tissue
Experimental: 5.8 hours; /20880 seconds; Mammalian: 3.5 hour; Yeast: 10 min; E. coli: >10 hour
PaperSource-linked PubMed record(s) for Glucagon-like peptide 1(7-36) (Canis lupus familiaris): PMID 15012592 PMID15012592 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15012592/
RECORD: Rec_0318426 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
GLP-1
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Insulinotropic
ELISA
Rabbit blood, in vivo; 90 s
PMID19552923 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19552923/
RECORD: Rec_0320748 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
GLP-1
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Pyroglutamate
None
Bio-Activity Profile
Insulinotropic
5600 μM
LC/MS equipped with a microbore C-18 HPLC
Human plasma, in vitro; >43200 s
PMID15012592 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15012592/
RECORD: Rec_0321584 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
GLP-1
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Insulinotropic
Radioimmunoassay
Rat plasma, in vivo; 195 s
PMID12039708 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12039708/
RECORD: Rec_0325980 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
GLP-1
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Insulin secretion stimulation Glucose clearance
0.0061±0.0018 μM
EC50
Human plasma+DPA (DPA is DPP inhibitor), in vitro; >43200 s
PMID15246869 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15246869/
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