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MYP_171785
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Basic Information
Glucagon like peptide 1 [7-36]
Binding / Molecular interaction ▸ Binding activity
Hormonal / Endocrine ▸ Hormone peptide
Metabolic
Metabolic ▸ Appetite and feeding regulation ▸ Feeding regulator
Metabolic ▸ Glucose metabolism ▸ Antidiabetic
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell-cell communication
Standard
30 amino acids
C149H225N39O46
Standard
Sequence
HAEGTFTSDVSSYLEGQAAKEFIAWLVKGR
Physicochemical Analysis
3298.61 Da
5.53
-1.15
-1.41
-0.0382
-0.23
0.48
0.08
17.69
71.67
0.1333
6990.00
6990.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1379.30
-13.40
49.0
46.0
108.0
234.0
6.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0108632 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
GLP-1
9606
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
Amidation
X-2 = Lys- conjugated-7-hydroxyCoumarin maleimide
Bio-Activity Profile
Receptor-binding
EC50
Rat Plasma, in vitro; 77760 s
PMID25039358 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25039358/
RECORD: Rec_0141689 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
GLP-1
9606
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
Amidation
X-2 = Cys- conjugated-7-hydroxyCoumarin maleimide
Bio-Activity Profile
Receptor-binding
EC50
Rat Plasma, in vitro; 187920 s
PMID25039358 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25039358/
RECORD: Rec_0158231 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
GLP-1
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Insulinotropic
a receptor
0.00037 μM
IC50
Intraperitoneally administered to adult obese diabetic (ob /ob ) mice, in vivo; <120 s
PMID15012592 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15012592/
RECORD: Rec_0166996 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
GLP-1
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Biotinylation at Lys at 34th and 26th position
Bio-Activity Profile
Insulinotropic
0.00385±0.00021 μM
EC50
Rat intestinal homogenate, in vitro; 166.2 s
PMID17904340 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17904340/
RECORD: Rec_0167635 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Glucagon-like peptide 1(7-36)
9606
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Amidation
8:Phosphoserine; 11:Phosphoserine
Bio-Activity Profile
Hormone Endocrine Neuropeptide Neuromodulator Metabolic regulation Physiological regulation Growth regulation Development regulation Receptor modulation Feeding regulator
peripheral tissue
Experimental: 5.8 hours; /20880 seconds; Mammalian: 3.5 hour; Yeast: 10 min; E. coli: >10 hour
PaperSource-linked PubMed record(s) for Glucagon-like peptide 1(7-36) (Homo sapiens): PMID 2753890##15012592 PMID2753890;15012592 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2753890/
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