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MYP_171785
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Basic Information
Glucagon like peptide 1 [7-36]
Binding / Molecular interaction ▸ Binding activity
Hormonal / Endocrine ▸ Hormone peptide
Metabolic
Metabolic ▸ Appetite and feeding regulation ▸ Feeding regulator
Metabolic ▸ Glucose metabolism ▸ Antidiabetic
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell-cell communication
Standard
30 amino acids
C149H225N39O46
Standard
Sequence
HAEGTFTSDVSSYLEGQAAKEFIAWLVKGR
Physicochemical Analysis
3298.61 Da
5.53
-1.15
-1.41
-0.0382
-0.23
0.48
0.08
17.69
71.67
0.1333
6990.00
6990.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1379.30
-13.40
49.0
46.0
108.0
234.0
6.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0038883 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
GLP-1
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antihyperglycemic Metabolic regulation
Radioactivity measurement
Pig kidney, in vivo; 288 s
PMID23318502 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23318502/
RECORD: Rec_0039553 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
glucagon family
9606; 0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
8-Ser: Phosphoserine; 11-Ser: Phosphoserine
Bio-Activity Profile
Hormone glucagon family
PaperPDB 1D0R structural record; NMR; chain A; residues 1-30
RECORD: Rec_0059616 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
GLP-1
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
None
Bio-Activity Profile
Insulinotropic
a receptor
IC50
Intraperitoneally administered to adult obese diabetic (ob /ob ) mice, in vivo; Completely resistant to degradation No units
PMID15012592 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15012592/
RECORD: Rec_0074165 VERIFIED: YES
Provenance & Taxonomy
Canis familiaris [Animal]
Glucagon
9615
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Hormone Metabolic
PMID2753890 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2753890/
RECORD: Rec_0082132 VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]
Glucagon-like peptide 1(7-36)
9823
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Amidation
8:Phosphoserine; 11:Phosphoserine
Bio-Activity Profile
Hormone Endocrine Metabolic regulation Physiological regulation Receptor modulation
Experimental: 5.8 hours; /20880 seconds; Mammalian: 3.5 hour; Yeast: 10 min; E. coli: >10 hour
PaperSource-linked PubMed record(s) for Glucagon-like peptide 1(7-36) (Sus scrofa): PMID 2753890##15012592 PMID2753890;15012592 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2753890/
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