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MYP_171727
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Basic Information
Pepstatin A
Antimicrobial
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
not Standard
5 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
VVXAX
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0228710 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protease/Proteasome inhibitor
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
None
Isovaleryl
Bio-Activity Profile
Antimicrobial Antiparasitic Antimalarial
Plasmodium falciparum It
4 μM
IC50; [3H] Hypoxanthine incorporation assay
PMID9736544 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9736544/
RECORD: Rec_0249121 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protease/Proteasome inhibitor
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
None
Isovaleryl, sta=statin
Bio-Activity Profile
Antimicrobial Antiparasitic Antimalarial
Plasmodium falciparum Δpfpm3 parasite line
20.0±3.7 μM
IC50; [3H] Hypoxanthine incorporation assay
PaperRole of Plasmodium falciparum digestive vacuole plasmepsins in the specificity and antimalarial mode of action of cysteine and aspartic protease inhibitors PMID19752273 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19752273/
RECORD: Rec_0305063 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protease/Proteasome inhibitor
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
None
Isovaleryl, sta=statin
Bio-Activity Profile
Antimicrobial Antiparasitic Antimalarial
Plasmodium falciparum 3D7 parasite line
16.4±1.1 μM
IC50; [3H] Hypoxanthine incorporation assay
PaperRole of Plasmodium falciparum digestive vacuole plasmepsins in the specificity and antimalarial mode of action of cysteine and aspartic protease inhibitors PMID19752273 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19752273/
RECORD: Rec_0344916 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protease/Proteasome inhibitor
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
None
Isovaleryl, sta=statin
Bio-Activity Profile
Antimicrobial Antiparasitic Antimalarial
Plasmodium falciparum Δ4pfpm parasite line
18.4±1.3 μM
IC50; [3H] Hypoxanthine incorporation assay
PaperRole of Plasmodium falciparum digestive vacuole plasmepsins in the specificity and antimalarial mode of action of cysteine and aspartic protease inhibitors PMID19752273 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19752273/
RECORD: Rec_0353399 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protease/Proteasome inhibitor
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
None
Isovaleryl, sta=statin
Bio-Activity Profile
Antimicrobial Antiparasitic Antimalarial
Plasmodium falciparum Δ4pfpm parasite line
11.5±1.3 μM
IC50; [3H] Hypoxanthine incorporation assay
PaperRole of Plasmodium falciparum digestive vacuole plasmepsins in the specificity and antimalarial mode of action of cysteine and aspartic protease inhibitors PMID19752273 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19752273/
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