Peptide Database

Peptide NameTachyplesin ccTP

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Venom / Toxin ▸ General toxin ▸ Toxic

Standard StatusStandard

Sequence Length18 amino acids

Chemical FormulaC95H143N29O21S6

DescriptionStandard

        KWCFCVCYRGICYCRCRG
    

Molecular Weight2219.72 Da

Isoelectric Point (pI)8.94

Net Charge (pH 7.0)3.70

Net Charge (pH 7.4) 3.40

Charge Density (pH 7.0) 0.2054

GRAVY Index0.27

Hydrophobic Moment 0.40

Boman Index-0.08

Instability Index-18.29

Aliphatic Index 37.78

Aromaticity 0.2222

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8855.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 825.99

LogP -6.03

H-bond Donors 38.0

H-bond Acceptors 31.0

Rotatable Bonds 68.0

Heavy Atoms 151.0

Ring Count 5.0

Amide Bonds 17.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0423898 VERIFIED: YES

Provenance & Taxonomy

OrganismSynthetic construct [Synthetic]

FamilyTachyplesin

Tax ID32630

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNo specific N-terminal

C-TermNo specific C-terminal

Disulfide3-16; 5-14; 7-12

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

Targetlow-salt; MIC=7.8 μM in high-salt)

Activity2.1 μM

MethodMIC

PaperMarked increase in membranolytic selectivity of novel cyclic tachyplesins constrained with an antiparallel two-beta strand cystine knot framework. Biochem Biophys Res Commun. 2000 Jan 27;267(3):783-790. doi: 10.1006/bbrc.1999.2035. PMID: 10673369. PMID10673369 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10673369/

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