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MYP_171718
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Basic Information
Tachyplesin ccTP
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
18 amino acids
C95H143N29O21S6
Standard
Sequence
KWCFCVCYRGICYCRCRG
Physicochemical Analysis
2219.72 Da
8.94
3.70
3.40
0.2054
0.27
0.40
-0.08
-18.29
37.78
0.2222
8480.00
8855.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
825.99
-6.03
38.0
31.0
68.0
151.0
5.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0031368 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Escherichia coli ATCC 25922
6.9 μM
MIC
PMID10673369 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10673369/
RECORD: Rec_0045681 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
Tachyplesin
32630
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
No specific N-terminal
No specific C-terminal
3-16; 5-14; 7-12
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
low-salt; MIC=6.9 μM in high-salt)
3 μM
MIC
PaperMarked increase in membranolytic selectivity of novel cyclic tachyplesins constrained with an antiparallel two-beta strand cystine knot framework. Biochem Biophys Res Commun. 2000 Jan 27;267(3):783-790. doi: 10.1006/bbrc.1999.2035. PMID: 10673369. PMID10673369 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10673369/
RECORD: Rec_0070813 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
Tachyplesin
32630
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
No specific N-terminal
No specific C-terminal
3-16; 5-14; 7-12
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
low-salt; MIC=1.1 μM in high-salt)
5.2 μM
MIC
PaperMarked increase in membranolytic selectivity of novel cyclic tachyplesins constrained with an antiparallel two-beta strand cystine knot framework. Biochem Biophys Res Commun. 2000 Jan 27;267(3):783-790. doi: 10.1006/bbrc.1999.2035. PMID: 10673369. PMID10673369 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10673369/
RECORD: Rec_0098310 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Candida kefyr ATCC 37095
3.9 μM
MIC
PMID10673369 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10673369/
RECORD: Rec_0102475 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Candida albicans ATCC 37092
5.1 μM
MIC
PMID10673369 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10673369/
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