Peptide Database

Peptide NameSyn-safencin-77

Function Ontology

Antiparasitic ▸ General antiparasitic ▸ Antiparasitic

Venom / Toxin ▸ General toxin ▸ Toxicity

Standard StatusStandard

Sequence Length25 amino acids

Chemical FormulaC140H230N42O33

DescriptionStandard

        AGKEKIRQYLKNEIKKKGRKAVWAW
    

Molecular Weight3029.59 Da

Isoelectric Point (pI)10.46

Net Charge (pH 7.0)6.79

Net Charge (pH 7.4) 6.59

Charge Density (pH 7.0) 0.2717

GRAVY Index-1.27

Hydrophobic Moment 0.65

Boman Index-0.36

Instability Index-1.00

Aliphatic Index 70.40

Aromaticity 0.1200

Extinction Coeff. Reduced 12490.00

Extinction Coeff. Oxidized 12490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1280.25

LogP -8.15

H-bond Donors 46.0

H-bond Acceptors 40.0

Rotatable Bonds 109.0

Heavy Atoms 215.0

Ring Count 5.0

Amide Bonds 26.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0106925 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyBacteriocin

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiparasitic

TargetL. donovani

Activity0.39 μM

MethodIC50

RECORD: Rec_0366598 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyBacteriocin

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiparasitic Toxicity

TargetTHP-1 cells

Activity>20 μM

MethodCC50