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MYP_171592
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Basic Information
Magainin A
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
23 amino acids
C115H182N30O29S
Standard
Sequence
AIGKFLHSAKKFGKAFVGEIMNS
Physicochemical Analysis
2480.92 Da
10.00
2.88
2.64
0.1253
0.18
0.69
0.18
3.59
76.52
0.1304
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
957.13
-7.50
33.0
34.0
86.0
175.0
4.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0281815 VERIFIED: YES
Provenance & Taxonomy
African clawed [Animal]
Magainin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Beta-alanine
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
NCI-H678
6.23 μM
IC50
PaperPubMed PMID: 1319823 PMID1319823 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1319823/
RECORD: Rec_0290919 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Beta-alanine
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anticancer
PaperCancerPPD: a database of anticancer peptides and proteins PMID25270878 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25270878/
RECORD: Rec_0302304 VERIFIED: YES
Provenance & Taxonomy
Xenopus laevis [Animal]
Magainin
8355
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Beta-alanine
Amidation
Bio-Activity Profile
Antibacterial
MLA
34 μg/mL
IC50
PaperAntibiotic magainins exert cytolytic activity against transformed cell lines through channel formation PMID1708887;2285300 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1708887/
RECORD: Rec_0322497 VERIFIED: YES
Provenance & Taxonomy
Xenopus laevis [Animal]
Magainin
8355
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Beta-alanine
Amidation
Bio-Activity Profile
Anticancer Cytotoxic
PC-3
53 μg/mL
IC50
PaperAntibiotic magainins exert cytolytic activity against transformed cell lines through channel formation PMID1708887;2285300 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1708887/
RECORD: Rec_0323001 VERIFIED: YES
Provenance & Taxonomy
African clawed [Animal]
Magainin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Beta-alanine
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
K562
40 μg/mL
IC50
PaperPubMed PMID: 1319823 PMID1319823 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1319823/
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