Peptide Database

Peptide NameSLAY-screened peptide P3440

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC99H154N28O32S2

DescriptionStandard

        DHPHVGRPSSILKICCYEEE
    

Molecular Weight2312.58 Da

Isoelectric Point (pI)5.46

Net Charge (pH 7.0)-2.07

Net Charge (pH 7.4) -2.42

Charge Density (pH 7.0) -0.1036

GRAVY Index-0.67

Hydrophobic Moment 0.34

Boman Index-0.09

Instability Index62.67

Aliphatic Index 73.00

Aromaticity 0.0500

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1615.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 953.81

LogP -8.77

H-bond Donors 34.0

H-bond Acceptors 34.0

Rotatable Bonds 73.0

Heavy Atoms 161.0

Ring Count 5.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0024482 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/