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MYP_171539
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Basic Information
LEDGF/p75 (355-377)
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV
Enzyme modulation ▸ Enzyme inhibition ▸ Integrase inhibition
Standard
23 amino acids
C113H193N33O36S
Standard
Sequence
IHAEIKNSLKIDNLDVNRCIEAL
Physicochemical Analysis
2622.01 Da
5.48
-1.16
-1.43
-0.0503
-0.05
0.44
-0.02
31.33
140.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1144.84
-10.20
39.0
37.0
92.0
183.0
1.0
25.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0038618 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
Human immunodeficiency virus (HIV): Inhibition of integrase activity (3' end processing)
165±28 μM
IC50
PaperPubMed PMID: 18331842 PMID18331842 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18331842/
RECORD: Rec_0042591 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV Integrase inhibition
Human immunodeficiency virus (HIV)
153±28 μM
IC50
Mammalian: 20 h; Yeast: 30 min; E. coli: >10 h
PaperInhibitory profile of a LEDGF/p75 peptide against HIV-1 integrase: insight into integrase-DNA complex formation and catalysis. | Al-Mawsawi LQ, Christ F, Dayam R, Debyser Z, Neamati N. | FEBS Lett. 2008 Apr 30;582(10):1425-30. | DOI:10.1016/j.febslet.2008.02.076 | PMID:18331842 PMID18331842 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18331842/
RECORD: Rec_0166701 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Integrase inhibition
25 μM
IC50
PaperInhibitory profile of a LEDGF/p75 peptide against HIV-1 integrase: insight into integrase-DNA complex formation and catalysis. PMID18331842 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18331842/
RECORD: Rec_0182448 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV Integrase inhibition
Human immunodeficiency virus (HIV)
165±28 μM
IC50
Mammalian: 20 h; Yeast: 30 min; E. coli: >10 h
PaperInhibitory profile of a LEDGF/p75 peptide against HIV-1 integrase: insight into integrase-DNA complex formation and catalysis. | Al-Mawsawi LQ, Christ F, Dayam R, Debyser Z, Neamati N. | FEBS Lett. 2008 Apr 30;582(10):1425-30. | DOI:10.1016/j.febslet.2008.02.076 | PMID:18331842 PMID18331842 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18331842/
RECORD: Rec_0294128 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
inhibition of integrase activity(strand transfer)
153±28 μM
IC50
PaperPubMed PMID: 18331842 PMID18331842 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18331842/
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