Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length479 amino acids

Chemical FormulaC2370H3782N644O661S11

DescriptionStandard

        MRAQSLVVACGALALCLALTGATNPGFVVRITQAGLDYAHQHAIAILEKELARLKLPDISGDFRFLGKVYYQISNLDLRTFHLPHSQISLVPNVGLQVSISNAFAELNGNWRVKYGLIRSSGSFNLKVENVYIRINLRLGSDSSGKPTVDTSSCSTRISKVRVRFLGKLSLVYNLFKKAVESRLRKALEGKVCDNVAKAVRNELQPYARTLPVTARIDSMTGIDYALVASPTATARSLDTGLKGEFFSLAHRATVPFPPLPLGLPPDHERMVYFGASSYFFNTASFAYHSAGALVFEISDSMIPGGADFRLNTSTFSAFIPQLETMYPKLPMKFRLSTRSAPFLSIGPGGFSLQPVVDVQAYAILPDATLAPLFLLSLTTNVSAVVDVTSGHIVGSLTVGRIKLSLKQSDVGAFQVRTLQSIMNIVASKILLPRVNARLGEGFPLPLPDRIQLSNILVRFHQNFLLLGADVQFQPQIGR
    

Molecular Weight52226.01 Da

Isoelectric Point (pI)9.85

Net Charge (pH 7.0)18.27

Net Charge (pH 7.4) 17.46

Charge Density (pH 7.0) 0.0381

GRAVY Index0.19

Hydrophobic Moment 0.78

Boman Index0.13

Instability Index32.28

Aliphatic Index 104.84

Aromaticity 0.0877

Extinction Coeff. Reduced 24870.00

Extinction Coeff. Oxidized 25120.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0247699 VERIFIED: NO

Provenance & Taxonomy

OrganismColumba livia [Animal]

FamilyBPI

Tax ID8932

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence