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MYP_171372
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Basic Information
Las[C8-C27, C17-C25]
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
27 amino acids
C129H238N38O28S4
Standard
Sequence
GLPRKILCAIAKKKGKCKGPLKLVCKC
Physicochemical Analysis
2897.77 Da
10.07
8.71
8.44
0.3227
0.07
0.62
-0.09
2.24
104.81
0.0000
0.00
250.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1072.40
-7.10
41.0
41.0
104.0
199.0
2.0
26.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0110021 VERIFIED: YES
Provenance & Taxonomy
Lasioglossum laticeps [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
8-25, 17-27
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Escherichia coli
3 μM
MIC
PMID22038181 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22038181/
RECORD: Rec_0111566 VERIFIED: YES
Provenance & Taxonomy
Lasioglossum laticeps [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
Pseudomonas aeruginosa
15 μM
MIC
PaperLasiocepsin, a novel cyclic antimicrobial peptide from the venom of eusocial bee Lasioglossum laticeps (Hymenoptera: Halictidae).
RECORD: Rec_0112748 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial
Human erythrocytes
200 μM
Hemolysis
PaperMonincová L, Slaninová J, Fučík V, et al. Lasiocepsin, a novel cyclic antimicrobial peptide from the venom of eusocial bee Lasioglossum laticeps (Hymenoptera: Halictidae). Amino Acids. 2012 Aug;43(2):751-761. doi:10.1007/s00726-011-1125-6. PMID22038181 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22038181/
RECORD: Rec_0114079 VERIFIED: YES
Provenance & Taxonomy
Lasioglossum laticeps [Animal]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Antiviral Hemolytic
human red blood cells
200 μM
LC50
PaperPubMed PMID: 22038181 PMID22038181 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22038181/
RECORD: Rec_0114325 VERIFIED: YES
Provenance & Taxonomy
Lasioglossum laticeps [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Bacillus subtilis
0.3 μM
MIC
PMID22038181 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22038181/
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