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MYP_171348
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Basic Information
S11VD (V681 peptide derivative)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
26 amino acids
C140H231N35O33
Standard
Sequence
KWKSFLKTFKVAVKTVLHTALKAISS
Physicochemical Analysis
2932.55 Da
10.70
5.84
5.58
0.2247
0.29
0.58
0.11
2.18
105.00
0.1154
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1112.79
-7.20
41.0
40.0
100.0
208.0
5.0
25.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0206205 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Aurein
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Acetylation
D-Val at 11
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Salmonella typhimurium C587
10.1 μg/mL
MIC
PMID15677462 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15677462/
RECORD: Rec_0219367 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Aurein
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Acetylation
D-Val at 11
Bio-Activity Profile
Hemolytic
Human red blood cells
125 μg/mL
MHC
PMID15677462 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15677462/
RECORD: Rec_0221406 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Salmonella typhimurium C587
10.1 μg/mL
MIC
PaperRational design of alpha-helical antimicrobial peptides with enhanced activities and specificity/therapeutic index. J Biol Chem. 2005 Apr 1;280(13):12316-29. doi: 10.1074/jbc.M413406200. PMID: 15677462. PMID15677462 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15677462/
RECORD: Rec_0250083 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Aurein
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Acetylation
D-Val at 11
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus SAP0017
8 μg/mL
MIC
PMID15677462 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15677462/
RECORD: Rec_0250159 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Aurein
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus 25923
16 μg/mL
MIC
PMID15677462 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15677462/
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