Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length240 amino acids

Chemical FormulaC1240H1908N302O330S11

DescriptionStandard

        MLLWEPAHGPSSFCLVMTKIDAVAGINYGLVAPPATTAETLDVQMKGEFYSENHHNPPPFAPPVMEFPAAHDRMVYLGLSDYFFNTAGLVYQEAGVLKMTLRDDMIPKESKFRLTTKFFGTFLPEVAKKFPNMKIQIHVSASTPPHLSVQPTGLTFYPAVDVQAFAILPNSSLASLFLIGMVALLQDIMNYIVPILVLPRVNEKLQKGFPLPTPARVQLYNVVLQPHQNFLLFGADVVYK
    

Molecular Weight26678.95 Da

Isoelectric Point (pI)6.65

Net Charge (pH 7.0)-0.89

Net Charge (pH 7.4) -1.52

Charge Density (pH 7.0) -0.0037

GRAVY Index0.21

Hydrophobic Moment 0.66

Boman Index0.21

Instability Index42.04

Aliphatic Index 96.67

Aromaticity 0.1125

Extinction Coeff. Reduced 18910.00

Extinction Coeff. Oxidized 18910.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0326441 VERIFIED: NO

Provenance & Taxonomy

OrganismPan paniscus [Animal]

FamilyBPI

Tax ID9597

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence