Peptide Database

Peptide NameGrammistin Pp3 (Group III grammistin; fish, chordates, animals)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Ichthyotoxic

Venom / Toxin ▸ General toxin ▸ Toxic

Venom / Toxin ▸ General toxin ▸ Toxin

Standard StatusStandard

Sequence Length25 amino acids

Chemical FormulaC118H192N32O33

DescriptionStandard

        NWRKILGQIASVGAGLLGSLLAGYE
    

Molecular Weight2586.98 Da

Isoelectric Point (pI)8.59

Net Charge (pH 7.0)0.77

Net Charge (pH 7.4) 0.56

Charge Density (pH 7.0) 0.0306

GRAVY Index0.52

Hydrophobic Moment 0.59

Boman Index0.31

Instability Index-3.44

Aliphatic Index 132.80

Aromaticity 0.0800

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 6990.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1049.60

LogP -8.72

H-bond Donors 37.0

H-bond Acceptors 34.0

Rotatable Bonds 86.0

Heavy Atoms 183.0

Ring Count 3.0

Amide Bonds 26.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0336493 VERIFIED: NO

Provenance & Taxonomy

OrganismPogonoperca punctata [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Toxin

RECORD: Rec_0359734 VERIFIED: YES

Provenance & Taxonomy

OrganismPogonoperca punctata [Animal]

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

TargetVibrio parahaemolyticus

Activity50 μg/mL

MethodMIC

RECORD: Rec_0385390 VERIFIED: NO

Provenance & Taxonomy

OrganismPogonoperca punctata [other]

FamilyGrammistin; Group 3 subfamily

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Anti-Gram-positive Cytolytic Toxin Hemolytic Ichthyotoxic

TargetGram-negative and Gram-positive bacteria

RECORD: Rec_0411954 VERIFIED: YES

Provenance & Taxonomy

OrganismPogonoperca punctata [Animal]

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Hemolytic

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