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MYP_170941
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Basic Information
JEV Ep (424-445)
Antimicrobial
Antiviral
Antiviral ▸ Anti-Flavivirus ▸ Anti-Japanese encephalitis virus
Enzyme modulation ▸ Enzyme inhibition ▸ Infection inhibition
Membrane / Ion-channel modulation ▸ Potassium channel modulation ▸ Potassium channel inhibitor
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
22 amino acids
C110H158N30O29
Standard
Sequence
AWDFGSIGGVFNSIGRAVHQVF
Physicochemical Analysis
2364.61 Da
6.79
-0.12
-0.36
-0.0053
0.51
0.76
0.35
8.30
84.09
0.1818
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
944.73
-8.51
33.0
30.0
73.0
169.0
6.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0019086 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-ZIKV Infection inhibition
Zika virus (ZIKV) | Vero cells
3.27 μM
IC50
Mammalian: 4.4 h; Yeast: >20 h; E. coli: >10 h
PaperAntiviral activity of peptide inhibitors derived from the protein E stem against Japanese encephalitis and Zika viruses. | Chen L, Liu Y, Wang S, Sun J, Wang P, Xin Q, Zhang L, Xiao G, Wang W. | Antiviral Res. 2017 May;141:140-149. | DOI:10.1016/j.antiviral.2017.02.009 | PMID:28232248 PMID28232248 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28232248/
RECORD: Rec_0037636 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
Zika virus (ZIKV):inhibition of Zika virus (ZIKV) infection in Vero cells
3.27 μM
IC50
PMID28232248 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28232248/
RECORD: Rec_0053709 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-JEV Infection inhibition
Japanese encephalitis virus (JEV)
0.00393 μM
IC50
Mammalian: 4.4 h; Yeast: >20 h; E. coli: >10 h
PaperAntiviral activity of peptide inhibitors derived from the protein E stem against Japanese encephalitis and Zika viruses. | Chen L, Liu Y, Wang S, Sun J, Wang P, Xin Q, Zhang L, Xiao G, Wang W. | Antiviral Res. 2017 May;141:140-149. | DOI:10.1016/j.antiviral.2017.02.009 | PMID:28232248 PMID28232248 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28232248/
RECORD: Rec_0084115 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
Japanese encephalitis virus (JEV):inhibition of JEV infection in BHK-21 (baby hamster kidney) cells
0.00393 μM
IC50
PMID28232248 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28232248/
RECORD: Rec_0300498 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
Baby Hamster Kidney cells BHK-21
25 % Cell death
Cell death
PMID28232248 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28232248/
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