Peptide Database

Peptide NameSyn-Protegrin-1, SynPG-1

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Standard StatusStandard

Sequence Length35 amino acids

Chemical FormulaC175H303N71O37S4

DescriptionStandard

        GLRRLLRKIRGRWKGGGRGGRLCYCRRRFCVCVGR
    

Molecular Weight4121.99 Da

Isoelectric Point (pI)11.93

Net Charge (pH 7.0)12.72

Net Charge (pH 7.4) 12.45

Charge Density (pH 7.0) 0.3634

GRAVY Index-0.62

Hydrophobic Moment 0.90

Boman Index-0.45

Instability Index80.32

Aliphatic Index 72.29

Aromaticity 0.0857

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 7240.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1821.68

LogP -18.74

H-bond Donors 77.0

H-bond Acceptors 54.0

Rotatable Bonds 143.0

Heavy Atoms 287.0

Ring Count 4.0

Amide Bonds 34.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0209905 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

TargetStaphylococcus pseudintermedius

Activity0.5 μg/mL

MethodMBC

RECORD: Rec_0212324 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyProtegrin

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitymixed L/D amino-acid peptide [Mixed]

Other ModsD-Gly at 1st, and 11th position, D-Leu at 2nd, 5th,and 6th position, D-Arg at 3rd, 4th, 7th, 10th, and 12th position, D-Lys at 8th, and 14th position, D-Ile at 9th position, D-Trp at 13th position

Bio-Activity Profile

Function

Antimicrobial Antibacterial

TargetSalmonella typhimurium

Activity4 μM

MethodMIBC

Half-LifePorcine serum: Incubated in 25% porcine serum for up to 7 or 24 h, maintained strong antimicrobial activity even after 24 h of incubation in serum

PaperMaystrenko A, Feng Y, Akhtar N, Li J. The Addition of a Synthetic LPS-Targeting Domain Improves Serum Stability While Maintaining Antimicrobial, Antibiofilm, and Cell Stimulating Properties of an Antimicrobial Peptide Biomolecules. 2020 Jul 8;10(7):1014. PMID:32650576 https://pubmed.ncbi.nlm.nih.gov/32650576/ PMID32650576 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32650576/

RECORD: Rec_0216416 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyProtegrin

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitymixed L/D amino-acid peptide [Mixed]

Other ModsD-Gly at 1st, and 11th position, D-Leu at 2nd, 5th,and 6th position, D-Arg at 3rd, 4th, 7th, 10th, and 12th position, D-Lys at 8th, and 14th position, D-Ile at 9th position, D-Trp at 13th position

Bio-Activity Profile

Function

Antimicrobial Antibacterial

TargetMethicillin-resistant Staphylococcus pseudointermedius

Activity0.5 μM

MethodMBC

Half-LifePorcine serum: Incubated in 25% porcine serum for up to 7 or 24 h, maintained strong antimicrobial activity even after 24 h of incubation in serum

PaperMaystrenko A, Feng Y, Akhtar N, Li J. The Addition of a Synthetic LPS-Targeting Domain Improves Serum Stability While Maintaining Antimicrobial, Antibiofilm, and Cell Stimulating Properties of an Antimicrobial Peptide Biomolecules. 2020 Jul 8;10(7):1014. PMID:32650576 https://pubmed.ncbi.nlm.nih.gov/32650576/ PMID32650576 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32650576/

RECORD: Rec_0354882 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyProtegrin

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitymixed L/D amino-acid peptide [Mixed]

Other ModsD-Gly at 1st, and 11th position, D-Leu at 2nd, 5th,and 6th position, D-Arg at 3rd, 4th, 7th, 10th, and 12th position, D-Lys at 8th, and 14th position, D-Ile at 9th position, D-Trp at 13th position

Bio-Activity Profile

Function

Antimicrobial Antibacterial

TargetMethicillin-resistant Staphylococcus aureus

Activity0.5 μM

MethodMBC

Half-LifePorcine serum: Incubated in 25% porcine serum for up to 7 or 24 h, maintained strong antimicrobial activity even after 24 h of incubation in serum

PaperMaystrenko A, Feng Y, Akhtar N, Li J. The Addition of a Synthetic LPS-Targeting Domain Improves Serum Stability While Maintaining Antimicrobial, Antibiofilm, and Cell Stimulating Properties of an Antimicrobial Peptide Biomolecules. 2020 Jul 8;10(7):1014. PMID:32650576 https://pubmed.ncbi.nlm.nih.gov/32650576/ PMID32650576 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32650576/

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