Peptide Database

Peptide NameUnnamed

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor

Standard StatusStandard

Sequence Length34 amino acids

Chemical FormulaC153H261N55O47S6

DescriptionStandard

        ARATCYCRTGRCATRESLSGVCEISGRLYRLCCR
    

Molecular Weight3815.44 Da

Isoelectric Point (pI)9.22

Net Charge (pH 7.0)4.74

Net Charge (pH 7.4) 4.46

Charge Density (pH 7.0) 0.1394

GRAVY Index-0.19

Hydrophobic Moment 0.71

Boman Index-0.26

Instability Index13.56

Aliphatic Index 63.24

Aromaticity 0.0588

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 3355.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1693.36

LogP -22.64

H-bond Donors 72.0

H-bond Acceptors 58.0

Rotatable Bonds 126.0

Heavy Atoms 261.0

Ring Count 2.0

Amide Bonds 33.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0018051 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide; DSSP H 0.0%, E 55.9%, T 23.5%, C 20.6% [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Antimicrobial

RECORD: Rec_0344489 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyDefensin

Tax ID9606;0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral Entry inhibitor

TargetBK virus (Virus entry); Vero

Activity98 %

MethodFlow cytometry

PaperHuman alpha-defensins inhibit BK virus infection by aggregating virions and blocking binding to host cells. | Dugan AS, Maginnis MS, Jordan JA, Gasparovic ML, Manley K, Page R, Williams G, Porter E, O'Hara BA, Atwood WJ. | J Biol Chem. 2008 | PMID:18782756 PMID18782756 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18782756/