Peptide Database

Peptide NameSLAY-screened peptide P4166

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length14 amino acids

Chemical FormulaC64H102N14O21

DescriptionStandard

        APLSPLGSLYTSTP
    

Molecular Weight1403.58 Da

Isoelectric Point (pI)5.57

Net Charge (pH 7.0)-0.21

Net Charge (pH 7.4) -0.39

Charge Density (pH 7.0) -0.0146

GRAVY Index0.21

Hydrophobic Moment 0.26

Boman Index0.30

Instability Index48.36

Aliphatic Index 90.71

Aromaticity 0.0714

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 536.63

LogP -6.30

H-bond Donors 18.0

H-bond Acceptors 21.0

Rotatable Bonds 37.0

Heavy Atoms 99.0

Ring Count 4.0

Amide Bonds 13.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0124883 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/