Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length162 amino acids

Chemical FormulaC819H1283N197O244S5

DescriptionStandard

        MEKPILKNLNEMLCPIIANEVEALNANLSTLEVLTKIDNYTLLDYSLISSPEITENYLDLNLKGVFYPLENLVDPYFSPVPFVLPERSNSMLYIGIAEYFFKSASFAYFTAGAFNVTLSTKEISNHFVQNSQGLGNVLSRVASTSVGLVILGQRLVCSLSLN
    

Molecular Weight17953.45 Da

Isoelectric Point (pI)4.66

Net Charge (pH 7.0)-6.41

Net Charge (pH 7.4) -6.75

Charge Density (pH 7.0) -0.0396

GRAVY Index0.28

Hydrophobic Moment 0.63

Boman Index0.20

Instability Index30.25

Aliphatic Index 113.09

Aromaticity 0.1049

Extinction Coeff. Reduced 11920.00

Extinction Coeff. Oxidized 12045.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 7051.31

LogP -64.05

H-bond Donors 239.0

H-bond Acceptors 244.0

Rotatable Bonds 586.0

Heavy Atoms 1265.0

Ring Count 26.0

Amide Bonds 179.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0382519 VERIFIED: NO

Provenance & Taxonomy

OrganismSaimiri boliviensis boliviensis [Animal]

FamilyBPI

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence