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MYP_170540
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Basic Information
Caerin 1.10
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Antiviral mechanism ▸ Viral release inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ nNOS inhibitor
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
25 amino acids
C121H207N31O30
Standard
Sequence
GLLSVLGSVAKHVLPHVVPVIAEKL
Physicochemical Analysis
2576.13 Da
8.61
0.94
0.63
0.0374
1.16
0.47
0.43
29.32
171.20
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
931.30
-4.40
31.0
33.0
82.0
182.0
4.0
24.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0294794 VERIFIED: YES
Provenance & Taxonomy
Litoria rothii [Animal]
Caerin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antiviral
Leuconostoc lactis
6 μg/mL
MIC
PMID26026377;16124032;10601876 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26026377/
RECORD: Rec_0300873 VERIFIED: YES
Provenance & Taxonomy
Litoria splendida [Animal]
Caerin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus epidermidis
100 μg/mL
MIC
PMID10601876 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10601876/
RECORD: Rec_0312805 VERIFIED: YES
Provenance & Taxonomy
Litoria splendida [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Antiviral Anticancer
MIC 25 ug/ml, Staphylococcus aureus ATCC 25923, or 29213
>100 μg/mL
MIC
PaperDifferences in the skin peptides of the male and female Australian tree frog Litoria splendida. The discovery of the aquatic male sex pheromone splendipherin, together with Phe8 caerulein and the antibiotic peptide caerin 1.10.
RECORD: Rec_0344396 VERIFIED: YES
Provenance & Taxonomy
Litoria rothii [Animal]
Caerin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antiviral
Staphylococcus epidermidis
100 μg/mL
MIC
PMID26026377;16124032;10601876 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26026377/
RECORD: Rec_0360282 VERIFIED: YES
Provenance & Taxonomy
Litoria splendida [Animal]
Caerin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
L. lactis
6 μg/mL
MIC
PMID10601876 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10601876/
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