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MYP_170540
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Basic Information
Caerin 1.10
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Antiviral mechanism ▸ Viral release inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ nNOS inhibitor
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
25 amino acids
C121H207N31O30
Standard
Sequence
GLLSVLGSVAKHVLPHVVPVIAEKL
Physicochemical Analysis
2576.13 Da
8.61
0.94
0.63
0.0374
1.16
0.47
0.43
29.32
171.20
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
931.30
-4.40
31.0
33.0
82.0
182.0
4.0
24.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0238675 VERIFIED: YES
Provenance & Taxonomy
Litoria splendida [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Antiviral Anticancer
Staphylococcus epidermidis
100 μg/mL
MIC
PaperDifferences in the skin peptides of the male and female Australian tree frog Litoria splendida. The discovery of the aquatic male sex pheromone splendipherin, together with Phe8 caerulein and the antibiotic peptide caerin 1.10.
RECORD: Rec_0253251 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PaperAntiCP 2.0: an updated model for predicting anticancer peptides (benchmark provenance; exact sequence-level experiment paper unresolved here) | https://pubmed.ncbi.nlm.nih.gov/32770192/
RECORD: Rec_0268300 VERIFIED: YES
Provenance & Taxonomy
Litoria rothii [Animal]
Caerin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antiviral
Virus:HIV: inhibition of HIV Pseudovirus (PsV) infection in CD4+ T cells
2.5 μM
IC50
PMID26026377;16124032;10601876 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26026377/
RECORD: Rec_0268684 VERIFIED: YES
Provenance & Taxonomy
Ranoidea splendida [Animal]
Frog skin active peptide (FSAP); Caerin subfamily
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative Anti-Gram-positive Non-hemolytic
Streptococcus uberis
PMID10601876 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10601876/
RECORD: Rec_0282718 VERIFIED: YES
Provenance & Taxonomy
Ranoidea splendida [Animal]
Frog skin active peptide (FSAP); Caerin subfamily
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative Anti-Gram-positive Non-hemolytic
Pasteurella multocida
PMID10601876 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10601876/
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