Peptide Database

Peptide NamespoIIP signal peptide

Function Ontology

Annotation / Sequence feature ▸ Signal peptide

Biotechnology / Production and expression ▸ Secretory enzyme production ▸ Cutinase secretion

Biotechnology / Production and expression ▸ Secretory expression optimization

Standard StatusStandard

Sequence Length39 amino acids

Chemical FormulaC200H342N58O46S

DescriptionStandard

        MRNKRRNRQIVVAVNGGKAVKAIFLFIVSLIVIFVLSGV
    

Molecular Weight4327.28 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)6.50

Net Charge (pH 7.4) 6.28

Charge Density (pH 7.0) 0.1666

GRAVY Index0.94

Hydrophobic Moment 0.48

Boman Index0.21

Instability Index38.06

Aliphatic Index 147.18

Aromaticity 0.0769

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1707.60

LogP -11.81

H-bond Donors 61.0

H-bond Acceptors 54.0

Rotatable Bonds 149.0

Heavy Atoms 305.0

Ring Count 3.0

Amide Bonds 42.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0363604 VERIFIED: YES

Provenance & Taxonomy

OrganismBacillus subtilis [Bacterium]

FamilySec signal peptide

Tax ID1423

Structure & Mods

Configlinear signal peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Protein secretion signal peptide Secretory expression optimization Cutinase secretion

TargetBacillus subtilis TEB1030

MethodSecretion phenotype assay

PaperBrockmeier U, Caspers M, Freudl R, et al. Systematic screening of all signal peptides from Bacillus subtilis: A powerful strategy in optimizing heterologous protein secretion in gram-positive bacteria[J]. Journal of Molecular Biology, 2006, 362(3): 393-402. PMID16930615 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16930615/