Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length426 amino acids

Chemical FormulaC2147H3369N567O597S11

DescriptionStandard

        AHQQGIAVLEKELAQLKLPDISGDFRIRHVGKVHYEISSLDLRSFHLPYSWISLVPNVGLQVAISNAFAEVDGNWRVKIYFIRDHGAFDLKVENVYIKINLKLGSDASGKPTVDTSDCSTRISKVRVHFSGKLGWLYNLFYGAVESRFRNILERKVCETAASSVRSDLQPYLRTLPVTARIDAMAGIDYSLVAPPTATAQSLDADLKGEFFSLAHRSAVPFPPLPLAFPPDHDRMVYFGASSYFFNTAGLAYHAAGVLVFDITDSMIPKDVEFHLNTSTFSAFVPQLEEMYPNMLMKLRLSAPSAPFLSIGPEGLSLKPVVDIQAYAILPSSSLAPLFLLSLVSNVSAVIDVKSGHIVGSLKVGRMKLSLKHSDVGTFQVRMLQSIMNIYASSILLPRVNGRLGQGFPLPLPDRIQLSNILVRFHQ
    

Molecular Weight47028.87 Da

Isoelectric Point (pI)9.00

Net Charge (pH 7.0)5.94

Net Charge (pH 7.4) 4.98

Charge Density (pH 7.0) 0.0139

GRAVY Index0.15

Hydrophobic Moment 0.66

Boman Index0.13

Instability Index36.67

Aliphatic Index 103.90

Aromaticity 0.0962

Extinction Coeff. Reduced 37360.00

Extinction Coeff. Oxidized 37485.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0053522 VERIFIED: NO

Provenance & Taxonomy

OrganismLeptosomus discolor [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria