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MYP_170470
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Basic Information
[E6k,D9k]Hymenochirin-1B
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Immunology ▸ Inflammation modulation ▸ Anti-inflammatory
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
29 amino acids
C142H263N39O33S
Standard
Sequence
IKLSPKTKKNLKKVLKGAIKGAIAVAKMV
Physicochemical Analysis
3076.91 Da
10.90
8.75
8.53
0.3018
0.14
0.69
0.01
6.77
124.48
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1187.06
-7.77
41.0
43.0
114.0
215.0
1.0
29.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0160528 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Proteus mirabilis ATCC 25933
100 μM
MIC
PMID24434793;24185042;24172540 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24434793/
RECORD: Rec_0164949 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Immunomodulatory Anti-inflammatory
mirabilis
100 μM
MIC
PaperAn analog of the host-defense peptide hymenochirin-1B with potent broad-spectrum activity against multidrug-resistant bacteria and immunomodulatory properties PMID24172540 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24172540/
RECORD: Rec_0166208 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Bio-Activity Profile
Anticancer Cytotoxic
Human lung carcinoma A549
1.0
LC50
PMID24434793;24185042;24172540 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24434793/
RECORD: Rec_0170985 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Immunomodulatory Anti-inflammatory Hemolytic
freshly prepared human erythrocytes
PaperAn analog of the host-defense peptide hymenochirin-1B with potent broad-spectrum activity against multidrug-resistant bacteria and immunomodulatory properties PMID24172540 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24172540/
RECORD: Rec_0185011 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Immunomodulatory Anti-inflammatory
Gram-positive bacteria: Staphylococcus aureus ATCC 29213
3.1 μM
MIC
PaperAn analog of the host-defense peptide hymenochirin-1B with potent broad-spectrum activity against multidrug-resistant bacteria and immunomodulatory properties PMID24172540 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24172540/
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