Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length141 amino acids

Chemical FormulaC694H1123N189O189S3

DescriptionStandard

        PVLLPAAREPMLLLGVTDFVANSAAFVYFTAGALRWTVTGSMLPRRFPLRLTTKSLGLFSPRLQELYPDEPVELRLSARRQPLLSCRPDGLRLALFGSAEAFVVLPNATRVSAFLLDIDANVTGKPLLTANRIGGSVSLVG
    

Molecular Weight15234.69 Da

Isoelectric Point (pI)10.35

Net Charge (pH 7.0)4.96

Net Charge (pH 7.4) 4.87

Charge Density (pH 7.0) 0.0352

GRAVY Index0.36

Hydrophobic Moment 0.54

Boman Index0.14

Instability Index44.67

Aliphatic Index 112.77

Aromaticity 0.0780

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8480.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 5955.54

LogP -52.20

H-bond Donors 211.0

H-bond Acceptors 197.0

Rotatable Bonds 485.0

Heavy Atoms 1075.0

Ring Count 24.0

Amide Bonds 146.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0092733 VERIFIED: NO

Provenance & Taxonomy

OrganismCasuarius casuarius (Southern cassowary) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria