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MYP_170270
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Basic Information
Alloferon (1-7)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
7 amino acids
C26H39N11O9
Standard
Sequence
HGVSGHG
Physicochemical Analysis
649.66 Da
6.92
-0.07
-0.37
-0.0094
-0.60
0.17
0.22
-21.06
41.43
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
315.51
-5.22
11.0
11.0
19.0
46.0
2.0
6.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0112960 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
Vero cells (- at NA
Hemolysis
PMID22883213 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22883213/
RECORD: Rec_0198751 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HSV-1 McIntyre strain
PMID22883213 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22883213/
RECORD: Rec_0250332 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Alloferon
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Entry inhibition
Herpesvirus 1 McIntire (HHV-1MC) | Vero cells
550 μM
IC50
Mammalian: 3.5 h; Yeast: 10 min; E. coli: >10 h
PaperNew alloferon analogues: synthesis and antiviral properties. | Kuczer M, Majewska A, Zahorska R. | Chem Biol Drug Des. 2013 Feb;81(2):302-9. | DOI:10.1111/cbdd.12020 | PMID:22883213 PMID22883213 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22883213/
RECORD: Rec_0263001 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Alloferon
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
Herpesvirus 1 McIntire (HHV-1MC):inhibition of virus replication in Vero cells
550 μM
IC50
PaperNew alloferon analogues: synthesis and antiviral properties. Chem Biol Drug Des. 2013 Feb;81(2):302-309. doi: 10.1111/cbdd.12020. PMID: 22883213. PMID22883213 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22883213/
RECORD: Rec_0263753 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Alloferon
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperNew alloferon analogues: synthesis and antiviral properties. Chem Biol Drug Des. 2013 Feb;81(2):302-309. doi: 10.1111/cbdd.12020. PMID: 22883213. PMID22883213 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22883213/
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