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MYP_170151
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Basic Information
Pore-forming peptide ameobapore A (EH-APP; saposin-like protein)
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Standard
77 amino acids
C362H605N93O112S6
Standard
Sequence
GEILCNLCTGLINTLENLLTTKGADKVKDYISSLCNKASGFIATLCTKVLDFGIDKLIQLIEDKVDANAICAKIHAC
Physicochemical Analysis
8244.62 Da
5.65
-1.21
-1.57
-0.0157
0.41
0.68
0.17
24.71
121.69
0.0390
1490.00
1865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
3308.30
-31.21
118.0
118.0
285.0
573.0
4.0
82.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0113521 VERIFIED: YES
Provenance & Taxonomy
Entamoeba histolytica [Protist]
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Bacillus megaterium
13 μM
MIC
PMID8146160 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8146160/
RECORD: Rec_0166635 VERIFIED: NO
Provenance & Taxonomy
Entamoeba histolytica [Animal]; Animalia [Animal]
33208; 33208
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0196546 VERIFIED: YES
Provenance & Taxonomy
Entamoeba histolytica [Protist]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
5-77; 8-71; 35-46
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Antibiotic
Bacillus subtilis (100% permeabilized bacteria: 5 nM)
PMID1881907;7715451;11948186 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1881907/
RECORD: Rec_0237383 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
RECORD: Rec_0249203 VERIFIED: YES
Provenance & Taxonomy
Entamoeba histolytica [Protist]
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Micrococcus luteus
1.9 μM
MIC
PMID8146160 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8146160/
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