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MYP_170151
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Basic Information
Pore-forming peptide ameobapore A (EH-APP; saposin-like protein)
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Standard
77 amino acids
C362H605N93O112S6
Standard
Sequence
GEILCNLCTGLINTLENLLTTKGADKVKDYISSLCNKASGFIATLCTKVLDFGIDKLIQLIEDKVDANAICAKIHAC
Physicochemical Analysis
8244.62 Da
5.65
-1.21
-1.57
-0.0157
0.41
0.68
0.17
24.71
121.69
0.0390
1490.00
1865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
3308.30
-31.21
118.0
118.0
285.0
573.0
4.0
82.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0007591 VERIFIED: YES
Provenance & Taxonomy
Entamoeba histolytica [Protist]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
5-77, 8-71, 35-46
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Bacillus subtilis
27 μM
MIC
PMID7715451;8146160;14970207 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7715451/
RECORD: Rec_0053097 VERIFIED: YES
Provenance & Taxonomy
Entamoeba histolytica [Protist]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
5-77, 8-71, 35-46
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
15 μM
MIC
PMID7715451;8146160;14970207 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7715451/
RECORD: Rec_0069564 VERIFIED: YES
Provenance & Taxonomy
Entamoeba histolytica [Protist]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
5-77; 8-71; 35-46
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Antibiotic
Gram-positive bacterium: Micrococcus luteus
2 μM
MIC
PMID1881907;7715451;11948186 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1881907/
RECORD: Rec_0073749 VERIFIED: YES
Provenance & Taxonomy
Entamoeba histolytica [Protist]
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Bacillus subtilis
27 μM
MIC
PMID8146160 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8146160/
RECORD: Rec_0096628 VERIFIED: YES
Provenance & Taxonomy
Entamoeba histolytica [Protist]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
5-77, 8-71, 35-46
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Micrococcus luteus
1.9 μM
MIC
PMID7715451;8146160;14970207 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7715451/
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