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MYP_170062
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Basic Information
C24
Antimicrobial
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor
Standard
24 amino acids
C114H199N35O40
Standard
Sequence
SISNALNKLEESNRNLDKVNVKLT
Physicochemical Analysis
2700.01 Da
8.22
0.46
0.25
0.0193
-0.72
0.66
-0.23
30.85
109.58
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1280.85
-16.30
43.0
41.0
97.0
189.0
0.0
28.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0177784 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 12127571 PMID12127571 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12127571/
RECORD: Rec_0178021 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-NDV Fusion inhibition
Newcastle disease virus (NDV) | NDV-infected cells
3.27 μM
IC50
Mammalian: 1.9 h; Yeast: >20 h; E. coli: >10 h
PaperMode of action of two inhibitory peptides from heptad repeat domains of the fusion protein of Newcastle disease virus. | San Román K, Villar E, Muñoz-Barroso I. | Int J Biochem Cell Biol. 2002 Oct;34(10):1207-20. | DOI:10.1016/s1357-2725(02)00045-6 | PMID:12127571 PMID12127571 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12127571/
RECORD: Rec_0201846 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
Newcastle disease virus (NDV):inhibition of syncytium formation between NDV-infected cells
3.27 μM
IC50
PaperPubMed PMID: 12127571 PMID12127571 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12127571/
RECORD: Rec_0275907 VERIFIED: YES
Provenance & Taxonomy
Avian orthoavulavirus 1 [Virus]
Heptad repeat peptide
2560319;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Fusion inhibitor
Newcastle disease virus (Fusion); Cos-7
3.27 μM
Syncytia assay
PaperMode of action of two inhibitory peptides from heptad repeat domains of the fusion protein of Newcastle disease virus. | San Roman K, Villar E, Munoz-Barroso I. | Int J Biochem Cell Biol. 2002 | PMID:12127571 PMID12127571 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12127571/
RECORD: Rec_0418901 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/