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MYP_169973
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Basic Information
Hyen D
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
30 amino acids
C138H212N34O40S6
Standard
Sequence
GFPCGESCVYIPCFTAAIGCSCKSKVCYKN
Physicochemical Analysis
3179.75 Da
8.32
1.70
1.40
0.0566
0.43
0.26
0.20
27.88
52.00
0.1333
2980.00
3355.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1169.47
-12.75
46.0
48.0
98.0
218.0
6.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0026242 VERIFIED: YES
Provenance & Taxonomy
medicinal herb Hybanthus enneaspermus [Plant]
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
PaperPubMed PMID: 32414842 PMID32414842 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32414842/
RECORD: Rec_0086663 VERIFIED: NO
Provenance & Taxonomy
Hybanthus enneaspermus [Plant]
Cyclotide
Structure & Mods
backbone-cyclized cyclotide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PaperCyclotide hyen-D Evidence URLhttps://www.uniprot.org/uniprotkb/C0HLN8/entry
RECORD: Rec_0109792 VERIFIED: YES
Provenance & Taxonomy
medicinal herb Hybanthus enneaspermus [Plant]
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
MCF-7
0.75±0.05 μM
CC50
PaperPubMed PMID: 32414842 PMID32414842 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32414842/
RECORD: Rec_0110647 VERIFIED: YES
Provenance & Taxonomy
medicinal herb Hybanthus enneaspermus [Plant]
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
K562
0.52±0.03 μM
CC50
PaperPubMed PMID: 32414842 PMID32414842 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32414842/
RECORD: Rec_0113220 VERIFIED: YES
Provenance & Taxonomy
Hybanthus enneaspermus [Plant]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PaperDiscovery and mechanistic studies of cytotoxic cyclotides from the medicinal herb Hybanthus enneaspermus
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