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MYP_169972
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Basic Information
[Ser7-O-¦ÂGlc(Ac)4]dermorphin
Antimicrobial
Binding / Molecular interaction ▸ Binding activity
Enzyme modulation ▸ Enzyme inhibition ▸ Inhibition of ileum cells contraction
Enzyme modulation ▸ Enzyme inhibition ▸ Inhibition of vas deferens cells contraction
Neurological / Signaling ▸ Analgesic/antinociceptive activity
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Analgesic
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Regulatory peptide ▸ Biological modulation
Standard
7 amino acids
C40H49N7O11
Standard
Sequence
YAFGYPS
Physicochemical Analysis
803.86 Da
5.52
-0.24
-0.45
-0.0346
-0.11
0.08
0.39
75.41
14.29
0.4286
2980.00
2980.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
289.82
-1.40
10.0
11.0
19.0
58.0
4.0
6.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0165849 VERIFIED: YES
Provenance & Taxonomy
Pachymedusa dacnicolor [Animal]
Dermorphin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Bio-Activity Profile
Inhibition of ileum cells contraction Inhibition of vas deferens cells contraction Mu-receptor affinity Delta-receptor affinity Antinociceptive
PaperK. Richter et al. / PNAS 87 (1990) 4836-4839. cDNAs encoding [D-Ala2]deltorphin precursors from skin of Phyllomedusa bicolor also contain genetic information for three dermorphin-related opioid peptides Evidence URLhttps://www.uniprot.org/uniprotkb/O93456/entry
RECORD: Rec_0169564 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Neuropeptide
Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/
RECORD: Rec_0201998 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Opioid
opioid receptor
PaperWechselberger C., Severini C., Kreil G., Negri L.. A new opioid peptide predicted from cloned cDNAs from skin of Pachymedusa donicolor and Agalychnis annae. FEBS Lett., 429, 41-43, 1998.
RECORD: Rec_0204078 VERIFIED: NO
Provenance & Taxonomy
Phyllomedusa hypochondrialis [Animal]
Dermorphin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
-
Evidence URLhttps://www.uniprot.org/uniprotkb/P84523/entry
RECORD: Rec_0210161 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa sauvagii [Animal]
Dermorphin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Bio-Activity Profile
Inhibition of ileum cells contraction Inhibition of vas deferens cells contraction Mu-receptor affinity Delta-receptor affinity Antinociceptive
PaperK. Richter et al. / PNAS 87 (1990) 4836-4839. cDNAs encoding [D-Ala2]deltorphin precursors from skin of Phyllomedusa bicolor also contain genetic information for three dermorphin-related opioid peptides Evidence URLhttps://www.uniprot.org/uniprotkb/P05422/entry
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