Peptide Database

Peptide NameIL-1 receptor antagonist

Function Ontology

Immunology ▸ Immune modulation ▸ Immunomodulatory activity

Neurological / Signaling ▸ Receptor modulation ▸ Agonist

Neurological / Signaling ▸ Receptor modulation ▸ Antagonist

Neurological / Signaling ▸ Signaling peptide

Standard StatusStandard

Sequence Length152 amino acids

Chemical FormulaC754H1177N207O231S9

DescriptionStandard

        RPSGRKSSKMQAFRIWDVNQKTFYLRNNQLVAGYLQGPNVNLEEKIDVVPIEPHALFLGIHGGKMCLSCVKSGDETRLQLEAVNITDLSENRKQDKRFAFIRSDSGPTTSFESAACPGWFLCTAMEADQPVSLTNMPDEGVMVTKFYFQEDE
    

Molecular Weight17126.24 Da

Isoelectric Point (pI)5.46

Net Charge (pH 7.0)-3.07

Net Charge (pH 7.4) -3.48

Charge Density (pH 7.0) -0.0202

GRAVY Index-0.43

Hydrophobic Moment 0.51

Boman Index-0.04

Instability Index63.47

Aliphatic Index 71.18

Aromaticity 0.0921

Extinction Coeff. Reduced 15470.00

Extinction Coeff. Oxidized 15720.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 7085.92

LogP -73.43

H-bond Donors 244.0

H-bond Acceptors 239.0

Rotatable Bonds 570.0

Heavy Atoms 1201.0

Ring Count 26.0

Amide Bonds 167.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0269631 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyGtoPdb endogenous peptide ligand

Tax ID9606

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidereported in GtoPdb PTM annotation

Other ModsN-linked glycosylation of asparagine residue at position 84; disulphide bond between cysteine residues at positions 66 and 116.

Bio-Activity Profile

Function

Receptor antagonist Immunomodulatory Signaling peptide

TargetInterleukin-1 receptor, type I (Human); Interleukin-2 receptor (Human)