Peptide Database

Peptide NamePotassium channel toxin alpha-KTx 6.15

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Toxic

Venom / Toxin ▸ General toxin ▸ Toxin

Standard StatusStandard

Sequence Length35 amino acids

Chemical FormulaC159H267N49O49S8

DescriptionStandard

        IKCTLSKDCYSPCKKETGCPRAKCINRNCKCYGCS
    

Molecular Weight3905.64 Da

Isoelectric Point (pI)9.05

Net Charge (pH 7.0)5.68

Net Charge (pH 7.4) 5.34

Charge Density (pH 7.0) 0.1622

GRAVY Index-0.63

Hydrophobic Moment 0.61

Boman Index-0.27

Instability Index28.20

Aliphatic Index 36.29

Aromaticity 0.0571

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 3480.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1617.45

LogP -21.22

H-bond Donors 65.0

H-bond Acceptors 63.0

Rotatable Bonds 131.0

Heavy Atoms 265.0

Ring Count 4.0

Amide Bonds 36.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0088667 VERIFIED: NO

Provenance & Taxonomy

OrganismHemiscorpius lepturus [Animal]

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide3-24; 9-29; 13-19; 31-34

Bio-Activity Profile

Function

Toxin

TargetXenopus oocytes with, Kv1, KCNA1, KCNA2, KCNA3

RECORD: Rec_0286862 VERIFIED: NO

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Toxic Cytotoxic